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[2] Buffer solutions which are used to correct acidosis or alkalosis are also administered through intravenous access

As high-energy-demand cells, cerebral neurons require continuous bioenergetic supply to power neurotransmitter biosynthesis and vesicular secretion, action potential propagation, and synaptic plasticity modulation

doi:10.1016/j.clinph.2014.12.021 Oghalai JS, Manolidis S, Barth JL, Stewart MG, Jenkins HA

Interestingly, all-trans retinoic acid (ATRA), an inhibitor of Pin1, inhibits the drug resistance of cells mainly by inhibiting the ERK 1/2 and AKT pathways ( Inhibition of epithelialmesenchymal transition (EMT)-like phenomena is also a direction to take to overcome drug resistance